Fibroblast growth factor 23 and soluble Klotho in patients with autosomal dominant polycystic kidney disease.

Abstract

AIM:

This study aimed to examine the roles of fibroblast growth factor 23 (FGF23) and soluble Klotho in phosphate metabolism in autosomal-dominant polycystic kidney disease (ADPKD) patients.

METHODS:

We measured these two factors and phosphate metabolism parameters in 80 patients with ADPKD and 53 patients with non-diabetic chronic kidney disease (CKD).

RESULTS:

The mean serum FGF23 level in the ADPKD group was significantly (twofold) higher than in the non-diabetic CKD patients, but the mean soluble Klotho level in the ADPKD group was significantly lower in the non-diabetic CKD group. The mean serum phosphate levels of the two groups were similar. The estimated glomerular filtration rate (eGFR) was approximately 45 mL/min per 1.73 m2 in both groups, and their serum vitamin D metabolite levels were in the normal range.

CONCLUSION:

The serum FGF23 levels were significantly higher and soluble Klotho levels significantly lower in the ADPKD group than in the non-diabetic CKD group matched for eGFR, and these findings may be associated with resistance of renal phosphate excretion.

• Authors: Kenichi Akiyama, Toshio Mochizuki, Hiroshi Kataoka, Ken Tsuchiya, Kosaku Nitta
• Journal: Nephrology (Carlton, Vic.) (Nephrology (Carlton)) Vol. 22 Issue 11 Pg. 848-853 (Nov 2017) ISSN: 1440-1797 [Electronic] Australia
• PMID: 27450645 (Publication Type: Journal Article)
• Copyright: © 2016 Asian Pacific Society of Nephrology.

Chemical References

• FGF23 protein, human
• Phosphates
• Fibroblast Growth Factors
• Fibroblast Growth Factor-23
• Glucuronidase
• Klotho Proteins

Topics

• Adult
• Aged
• Female
• Fibroblast Growth Factor-23
• Fibroblast Growth Factors (blood, physiology)
• Glomerular Filtration Rate
• Glucuronidase (blood, physiology)
• Humans
• Klotho Proteins
• Male
• Middle Aged
• Phosphates (metabolism)
• Polycystic Kidney, Autosomal Dominant (blood, physiopathology)