Efficacy of Subgingivally Delivered 1.2% Atorvastatin in the Treatment of Chronic Periodontitis in Patients With Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial.

Abstract

BACKGROUND:

The present study was designed to evaluate effectiveness of 1.2% atorvastatin (ATV) gel, as an adjunct to scaling and root planing (SRP) in the treatment of intrabony defects in chronic periodontitis (CP) in patients with type 2 diabetes mellitus (t2DM).

METHODS:

Seventy-five patients were categorized into two treatment groups: 1) SRP plus 1.2% ATV and 2) SRP plus placebo. Clinical parameters including modified sulcus bleeding index, probing depth (PD), and relative attachment level (RAL) were recorded at baseline and 3, 6, and 9 months. Percentage radiographic defect depth reduction was evaluated using computer-aided software at baseline and 6 and 9 months.

RESULTS:

Mean PD reduction and mean RAL gain was greater in the ATV group than the placebo group at 3, 6, and 9 months. Furthermore, ATV group sites presented with a significantly greater percentage of radiographic defect depth reduction at 6 and 9 months.

CONCLUSION:

Locally delivered ATV was found to be effective in treatment of intrabony defects in CP in patients with t2DM.

• Authors: Minal Kumari, Santosh S Martande, A R Pradeep, Savitha B Naik
• Journal: Journal of periodontology (J Periodontol) Vol. 87 Issue 11 Pg. 1278-1285 (Nov 2016) ISSN: 1943-3670 [Electronic] United States
• PMID: 27442085 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Atorvastatin

Topics

• Alveolar Bone Loss
• Anti-Bacterial Agents
• Atorvastatin (therapeutic use)
• Chronic Periodontitis (complications, drug therapy)
• Dental Scaling
• Diabetes Mellitus, Type 2 (complications)
• Follow-Up Studies
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)
• Periodontal Index
• Root Planing