A new enhanced antibiotic treatment for early and late syphilis.
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| Abstract |
The objective of this study was to evaluate the efficacy of an enhanced treatment regimen for syphilis with the addition of doxycycline and ceftriaxone to the conventional benzathine penicillin G (BPG) treatment. Sixty-nine syphilis patients were recruited and were randomly assigned to two groups: group 1 (38 patients) received standard therapy and group 2 (31 patients) received the enhanced therapy. All patients were followed-up for at least 12 months. Patients underwent physical examination and serology every 6 months as well as echocardiography and neurological examination every year. A three- to four-fold decline in the initial Venereal Disease Research Laboratory (VDRL) titre within 6 months after therapy was considered as serological cure. At 12 months, 68% of patients in group 1 and 100% in group 2 were serologically cured (P=0.002). During follow-up, no patients in group 2 experienced complications related to syphilis. In contrast, one patient in group 1 developed neurosyphilis. In conclusion, the enhanced treatment is more effective than standard treatment and results in a higher and faster cure rate. Moreover, it provides treponemicidal antibiotic levels in the cerebrospinal fluid, thereby preventing possible late complications.
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| Authors | Francesco Drago, Giulia Ciccarese, Francesco Broccolo, Giulia Sartoris, Paola Stura, Susanna Esposito, Alfredo Rebora, Aurora Parodi |
| Journal | Journal of global antimicrobial resistance (J Glob Antimicrob Resist) Vol. 5 Pg. 64-6 (06 2016) ISSN: 2213-7173 [Electronic] Netherlands |
| PMID | 27436469 (Publication Type: Journal Article, Randomized Controlled Trial) |
| Copyright | Copyright © 2016 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved. |
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