Autoantibodies in Sjögren's Syndrome.

Abstract

We compiled information on antibodies in Sjögren syndrome, focusing more on clinical manifestations associated with anti-Ro/SSA and anti-La/SSB antibodies and studies regarding novel antibodies. We reviewed previous as well as most recent studies with the subject heading Sjogren in combination with antibodies and congenital heart block (CHB). Almost half of asymptomatic mothers giving birth to children with CHB ultimately develop Sjögren. We discussed studies concerning the presence of antibodies predating clinical manifestations of disease. Studies in the future are required to ascertain the pathogenic mechanisms associated with these antibodies and the specific clinical manifestation related to new autoantibodies.

• Authors: Anum Fayyaz, Biji T Kurien, R Hal Scofield
• Journal: Rheumatic diseases clinics of North America (Rheum Dis Clin North Am) Vol. 42 Issue 3 Pg. 419-34 (08 2016) ISSN: 1558-3163 [Electronic] United States
• PMID: 27431345 (Publication Type: Journal Article, Review)
• Copyright: Published by Elsevier Inc.

Chemical References

• Antibodies, Antinuclear
• Autoantibodies
• Peptides, Cyclic
• Receptor, Muscarinic M3
• SS-A antibodies
• SS-B antibodies
• anticentromere antibody
• cyclic citrullinated peptide
• Rheumatoid Factor

Topics

• Antibodies, Antinuclear (immunology)
• Autoantibodies (immunology, metabolism)
• Disease Progression
• Female
• Heart Block (congenital, immunology)
• Humans
• Infant, Newborn
• Lupus Erythematosus, Systemic (congenital, immunology)
• Peptides, Cyclic (immunology)
• Pregnancy
• Receptor, Muscarinic M3 (immunology)
• Rheumatoid Factor (immunology)
• Sjogren's Syndrome (immunology)