[Pathogenic factors in calcium oxalate stones: Epidemiological investigation].

Abstract

INTRODUCTION:

Calcium oxalate stones are the most common urolithiasis. Changes in dietary habits, socio-economic and health status of populations explain its progression. The aim of our study was to determine metabolic factors leading to lithiasis and clarify its causes.

PATIENTS AND METHODS:

This is a retrospective study of 100 patients with calcium oxalate stones identified by morpho-constitutional study, collected in our department over a period of 5 years (2008-2013). We analyzed clinical, radiological and metabolic data.

RESULTS:

They were 73 men and 27 women (gender ratio: 2.7), aged meanly of 44.8 years. Dietary survey revealed inadequate calcium intake in 87% of cases. Urinary abnormalities were hypocitraturia (34%), hypomagnesuria (32%) and outflow hypercalciuria (21%). Crystalluria was positive in 44% of cases. Whewellite was the most common crystalline form. Calculi were bilateral (53%), renal (85%) and mainly collected after urological procedures (74%). Infrared analysis showed that 81% of stones have a heterogeneous composition. Pure Whewellite or combined with other compounds was the most frequent (31%). Idiopathic calcium oxalate lithiasis was the most common etiology (69%). Among secondary etiologies, diabetes was most frequently found (10%).

CONCLUSION:

Our epidemiological study of calcium oxalate stones has allowed us to identify the high frequency of food hyperoxaluria partly explained by a low calcium intake and a diet rich in oxalate phytotherapy.

LEVEL OF EVIDENCE:

4.

• Authors: H Kaaroud El Jery, A Harzallah, S Chouchi, E Talbi, H Baccouch, J Abdelmoula, A Bouzouita, M Chebil, F Ben Hamida, T Ben Abdallah
• Journal: Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie (Prog Urol) Vol. 26 Issue 8 Pg. 450-6 (Jun 2016) ISSN: 1166-7087 [Print] France
• Vernacular Title: Recherche de facteurs lithogènes au cours des lithiases oxalo-calciques : enquête épidémiologique.
• PMID: 27430498 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Chemical References

• Calcium Oxalate

Topics

• Adolescent
• Adult
• Aged
• Calcium Oxalate (analysis)
• Epidemiologic Studies
• Female
• Humans
• Male
• Middle Aged
• Retrospective Studies
• Risk Factors
• Urolithiasis (epidemiology)
• Young Adult