Abstract | BACKGROUND/AIMS: METHODS: In this cross-sectional study, fatigue score was calculated on the basis of questionnaire responses in HD patients. Participants were divided into 3 groups according to their hemoglobin (Hb) levels (low, normal and high). Iron deficiency was assessed as a transferrin saturation (TSAT) of <20%. RESULTS: We included 571 HD patients (men/women 368/203; mean age 62.2 ± 10.8 years). Among the 3 groups, fatigue scores increased significantly with decreasing Hb levels. HD patients with low Hb levels (<90 g/l) had significantly higher fatigue scores than those with higher Hb levels (≥120 g/l). In the multiple regression analysis, we showed that a high ERI (β = 0.208) and a low TSAT (β = -0.155), but not the Hb level, were significantly associated with increased fatigue score. Moreover, this was independent of age, gender and modifiable confounders linked to anemia. Even after restricting patients to those without iron deficiency (TSAT ≥20%), the ERI (β = 0.258) retained a significant and independent association with the fatigue score. CONCLUSION:
|
Authors | Akiyo Yamasaki, Koichiro Yoda, Hidenori Koyama, Shinsuke Yamada, Yoshihiro Tsujimoto, Senji Okuno, Shigeki Okada, Masaaki Inaba |
Journal | Nephron
(Nephron)
Vol. 134
Issue 2
Pg. 95-102
( 2016)
ISSN: 2235-3186 [Electronic] Switzerland |
PMID | 27424040
(Publication Type: Journal Article)
|
Copyright | © 2016 S. Karger AG, Basel. |
Chemical References |
|
Topics |
- Aged
- Cross-Sectional Studies
- Erythropoietin
(adverse effects)
- Fatigue
(chemically induced)
- Female
- Humans
- Male
- Middle Aged
- Multivariate Analysis
- Renal Dialysis
|