Abstract | OBJECTIVE: DESIGN: Cross-sectional study comparing 50 patients with FHH to age- and gender-matched controls. RESULTS: Studied subjects (69% women) had a mean age of 56years. A similar number of patients and controls (33%) were on treatment with antihypertensive drugs. Overall, no differences were found between groups in 24-h ambulatory BP or pulse wave velocity. However, compared with controls, diastolic BP during nighttime was lower in FHH females (60±5 vs 66±9mmHg, P<0.01) and higher in FHH males (69±6 vs 64±5mmHg, P=0.02). FHH was associated with a significantly higher plasma osmolality (P<0.01), higher plasma levels of vasopressin (P<0.01) and a higher renal excretion of epithelial sodium channels (ENaCs) (P=0.03), whereas urine aquaporin-2 and plasma sodium, aldosterone and renin did not differ between groups. FHH patients had a lower urinary volume with an increased osmolality if analyses were restricted to those not on treatments with antihypertensive drugs. CONCLUSIONS: FHH does not seem to be associated with an increased risk of CVD.
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Authors | Niels Frederik Breum Jakobsen, Esben Laugesen, Lars Rolighed, Peter H Nissen, Per Løgstrup Poulsen, Erling Bjerregaard Pedersen, Leif Mosekilde, Lars Rejnmark |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 175
Issue 4
Pg. 299-309
(Oct 2016)
ISSN: 1479-683X [Electronic] England |
PMID | 27418061
(Publication Type: Journal Article)
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Copyright | © 2016 European Society of Endocrinology. |
Chemical References |
- Receptors, Calcium-Sensing
- Vasopressins
- Aldosterone
- Sodium
- Renin
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Topics |
- Aldosterone
(blood)
- Blood Pressure
(physiology)
- Cardiovascular System
(physiopathology)
- Cross-Sectional Studies
- Female
- Humans
- Hypercalcemia
(blood, congenital, genetics, physiopathology)
- Male
- Middle Aged
- Receptors, Calcium-Sensing
(genetics)
- Renin
(blood)
- Sodium
(blood)
- Vascular Stiffness
(physiology)
- Vasopressins
(blood)
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