Therapeutic Modulation of Aortic Stiffness.

Abstract

Aortic stiffness (AS) is an important predictor of cardiovascular morbidity in humans. The present review discusses the possible pathophysiological mechanisms of AS and focuses on a survey of different therapeutic modalities for decreasing AS. The influence of several nonpharmacological interventions is described: decrease body weight, diet, aerobic exercise training, music, and continuous positive airway pressure therapy. The effects of different pharmacological drug classes on AS are also discussed: antihypertensive drugs-renin-angiotensin-aldosterone system drugs, beta-blockers, alpha-blockers, diuretics, and calcium channel blockers (CCBs)-advanced glycation end product cross-link breakers, statins, oral anti-diabetics, anti-inflammatory drugs, vitamin D, antioxidant vitamins, and endothelin-1 receptor antagonists. All of these have shown some effect in decreasing AS.

• Authors: Ahmed Muzhir Hussein, Ghazwan Shaaya, Rohit Arora, Ali Al-Khazaali, Khalid Al-Khafaji, Hanan K Helu
• Journal: American journal of therapeutics (Am J Ther) 2016 Nov/Dec Vol. 23 Issue 6 Pg. e1644-e1653 ISSN: 1536-3686 [Electronic] United States
• PMID: 27415977 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents
• Antihypertensive Agents
• Antioxidants
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Hypoglycemic Agents
• Receptor, Endothelin A
• Vitamin D

Topics

• Anti-Inflammatory Agents (therapeutic use)
• Antihypertensive Agents (therapeutic use)
• Antioxidants (therapeutic use)
• Aortic Diseases (physiopathology, therapy)
• Continuous Positive Airway Pressure
• Diet
• Exercise
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)
• Hypoglycemic Agents (therapeutic use)
• Receptor, Endothelin A (agonists)
• Vascular Stiffness (drug effects, physiology)
• Vitamin D (therapeutic use)
• Weight Loss