Abstract | BACKGROUND: METHODS: We systematically searched biomedical electronic databases and conference proceedings through February 2016. Two reviewers independently assessed all studies for relevance and validity. RESULTS: Overall, three studies were eligible for inclusion in this meta-analysis, which included a total of 585 patients, with 317 in ATRA plus ATO group and 268 in ATRA plus chemotherapy group. Compared with patients who received ATRA and chemotherapy, patients who received ATRA plus ATO had a significantly better event-free survival (hazard ratio [HR] = 0.38, 95% confidence interval [CI]: 0.22-0.67, p = 0.009), overall survival (HR = 0.44, 95% CI: 0.24-0.82, p = 0.009), complete remission rate (relative risk [RR] = 1.05; 95% CI: 1.01-1.10; p = 0.03). There were no significant differences in early mortality (RR = 0.48; 95% CI: 0.22-1.05; p = 0.07). CONCLUSION: Thus, this analysis indicated that ATRA plus ATO protocol may be preferred to standard ATRA plus chemotherapy protocol, particularly in low-to-intermediate risk APL patients. Further larger trials were needed to provide more evidence in high-risk APL patients.
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Authors | Yafang Ma, Lu Liu, Jie Jin, Yinjun Lou |
Journal | PloS one
(PLoS One)
Vol. 11
Issue 7
Pg. e0158760
( 2016)
ISSN: 1932-6203 [Electronic] United States |
PMID | 27391027
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- Antineoplastic Agents
- Arsenicals
- Oxides
- Tretinoin
- Arsenic Trioxide
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Topics |
- Antineoplastic Agents
(therapeutic use)
- Arsenic Trioxide
- Arsenicals
(therapeutic use)
- Humans
- Leukemia, Promyelocytic, Acute
(drug therapy)
- Oxides
(therapeutic use)
- Treatment Outcome
- Tretinoin
(therapeutic use)
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