Effects of serostatus and gender on the HRV-16-induced local immune response.

Abstract

The "experimental cold model" is widely used to investigate effects of HRV infection. However, effects of serostatus and gender on the HRV-induced immune response have not been clarified. 40 healthy seropositive and seronegative (1:1) male and female (1:1) subjects were inoculated with HRV-16. HRV infection increased viral load in nasal wash, which tended to be more pronounced in seronegative subjects. Furthermore, HRV infection increased levels of IP-10, IL-6, and IL-10 and leukocyte numbers in nasal wash of seronegative, but not of seropositive subjects. No differences in any of the parameters were found between both sexes. The HRV-induced local immune response is diminished in seropositive subjects compared with seronegative subjects, while gender does not influence this response. These results have important implications for the design of future experimental cold studies: seronegative subjects, from both sexes can be included.

• Authors: Rebecca M Koch, Matthijs Kox, Peter Pickkers, Marien I de Jonge, Radboudumc Immunoforce group
• Journal: Vaccine (Vaccine) Vol. 34 Issue 35 Pg. 4087-4091 (07 29 2016) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 27389172 (Publication Type: Clinical Trial, Phase I, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2016. Published by Elsevier Ltd.

Chemical References

• Antibodies, Viral
• CXCL10 protein, human
• Chemokine CXCL10
• IL10 protein, human
• IL6 protein, human
• Interleukin-6
• Interleukin-10

Topics

• Antibodies, Viral (blood)
• Chemokine CXCL10 (immunology)
• Female
• Humans
• Interleukin-10 (immunology)
• Interleukin-6 (immunology)
• Leukocyte Count
• Male
• Picornaviridae Infections (immunology)
• Rhinovirus
• Viral Load