Prospective study in a cohort of HIV-infected patients in Belgium from 2009 to 2013.
RESULTS: 759 patients were followed for a total of 2136 patient years. The incidence of
fever was low, with an incidence rate of 0.103 (95% CI 0.078; 0.135) febrile episodes per patient per year for temperature 38.3 °C or higher measured by a health care provider. Gender, age, ethnicity, and calendar year of measurement were no significant risk factors for
fever in univariable analysis, but recent HIV diagnosis, prior
AIDS, nadir CD4 cell count, last CD4 cell count, and viral load were, as were use of antiretroviral
therapy, recent start of antiretroviral
therapy and recent switch of antiretroviral
therapy. Recent stop of antiretroviral
therapy was no significant risk factor. In multivariable analysis prior
AIDS, last CD4 and viral load remained significant risk factors, but use of antiretroviral
therapy not.
CONCLUSION: In this contemporary cohort, incidence of
fever was low but CD4 cell count less than 200/mm³ remained associated with the highest incidence of
fever.