Abstract | OBJECTIVE: METHODS: Neuronal cell lines were exposed to anti- hnRNP A1 and isotype-matched control antibodies in vitro and examined for neuronal granule formation, including stress granules, P bodies and transport granules. In addition, RNAs that bound hnRNP A1 were determined. Levels of RNA and their translated proteins were measured upon exposure to the anti- hnRNP A1 antibodies. RESULTS: CONCLUSIONS: Taken together, these data suggest potential mechanisms by which autoantibodies may contribute to neurodegeneration in MS.
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Authors | Joshua N Douglas, Lidia A Gardner, Hannah E Salapa, Michael C Levin |
Journal | Journal of clinical & cellular immunology
(J Clin Cell Immunol)
Vol. 7
Issue 2
Pg. 402
(Apr 2016)
ISSN: 2155-9899 [Print] United States |
PMID | 27375925
(Publication Type: Journal Article)
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