WONOEP appraisal: Molecular and cellular biomarkers for epilepsy.

Abstract

Peripheral biomarkers have myriad potential uses for treatment, prediction, prognostication, and pharmacovigilance in epilepsy. To date, no single peripheral biomarker has demonstrated proven effectiveness, although multiple candidates are in development. In this review, we discuss the major areas of focus including inflammation, blood-brain barrier dysfunction, redox alterations, metabolism, hormones and growth factors.

• Authors: Lauren E Walker, Damir Janigro, Uwe Heinemann, Raili Riikonen, Christophe Bernard, Manisha Patel
• Journal: Epilepsia (Epilepsia) Vol. 57 Issue 9 Pg. 1354-62 (09 2016) ISSN: 1528-1167 [Electronic] United States
• PMID: 27374986 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: Wiley Periodicals, Inc. © 2016 International League Against Epilepsy.

Chemical References

• Biomarkers
• Intercellular Signaling Peptides and Proteins

Topics

• Animals
• Biomarkers (metabolism)
• Blood-Brain Barrier (physiopathology)
• Epilepsy (genetics, metabolism)
• Humans
• Inflammation (metabolism)
• Intercellular Signaling Peptides and Proteins (genetics, metabolism)