Contribution of Matrix Metallopeptidase-1 Genotypes, Smoking, Alcohol Drinking and Areca Chewing to Nasopharyngeal Carcinoma Susceptibility.

Abstract

BACKGROUND/AIM:

The up-regulation of matrix metalloproteinase-1 (MMP-1) has been demonstrated to be correlated with lymph node metastasis of nasopharyngeal carcinoma (NPC); however, the genotypic role of MMP-1 is not well understand. The present study aimed to assess the contribution of MMP-1 promoter -1607 genotypes, combined with environmental carcinogens, on the predisposition to NPC tumorigenesis.

MATERIALS AND METHODS:

The MMP-1 promoter -1607 genotypes were examined for 352 age- and gender-matched controls and 176 NPC patients by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology.

RESULTS:

We found that the MMP-1 promoter -1607 heterozygous 1G/2G and homozygous 1G/1G genotypes, were more and more prone to be associated with NPC risk (odds ratio (OR)=0.64 and 0.63, 95% confidence interval (CI)=0.43-1.03 and 0.36-0.96, p=0.0659 and 0.0932, respectively). In the dominant models, there was a significant association between the genotype of MMP-1 promoter -1607 and NPC risk (OR=0.64, 95% CI=0.43-0.91, p=0.0359). In addition, individuals carrying the 1G allele at MMP-1 promoter -1607 were less susceptible to NPC (OR=0.73; 95%CI=0.59 to 0.96, p=0.0418) after adjustment for age, gender, cigarette, alcohol and areca consumption.

CONCLUSION:

The 1G/1G genotype of MMP-1 promoter -1607 may independently have a protective effect on NPC risk, without interaction with behavioral factors, including cigarette, alcohol and areca consumption.

• Authors: Chia-Wen Tsai, Wen-Shin Chang, Chi-Li Gong, Liang-Chun Shih, Liang-Yu Chen, En-Yuan Lin, Hsin-Ting Li, Shiou-Ting Yen, Cheng-Nan Wu, DA-Tian Bau
• Journal: Anticancer research (Anticancer Res) Vol. 36 Issue 7 Pg. 3335-40 (Jul 2016) ISSN: 1791-7530 [Electronic] Greece
• PMID: 27354591 (Publication Type: Journal Article)
• Copyright: Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• MMP1 protein, human
• Matrix Metalloproteinase 1

Topics

• Alcohol Drinking (genetics, metabolism)
• Areca
• Case-Control Studies
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Male
• Matrix Metalloproteinase 1 (genetics, metabolism)
• Middle Aged
• Nasopharyngeal Neoplasms (enzymology, etiology, genetics)
• Polymerase Chain Reaction
• Polymorphism, Restriction Fragment Length
• Promoter Regions, Genetic
• Smoking (genetics, metabolism)