Diagnosis, Prevention, and Management of Statin Adverse Effects and Intolerance: Canadian Consensus Working Group Update (2016).

Abstract	The Canadian Consensus Working Group has updated its evaluation of the literature pertaining to statin intolerance and adverse effects. This overview introduces a pragmatic definition of statin intolerance (goal-inhibiting statin intolerance) that emphasizes the effects of symptoms on achieving nationally vetted goals in patients fulfilling indications for lipid-lowering therapy and cardiovascular risk reduction. The Canadian Consensus Working Group provides a structured framework for avoiding, evaluating and managing goal-inhibiting statin intolerance. Particularly difficult practice situations are reviewed, including management in young and elderly individuals, and in athletes and labourers. Finally, targeted at specialty practitioners, more detailed analyses of specific but more unusual adverse effects ascribed to statins are updated including evidence regarding new-onset diabetes, cognitive dysfunction, cataracts, and the rare but important immune-mediated necrotizing myopathy.
Authors	G B John Mancini, Steven Baker, Jean Bergeron, David Fitchett, Jiri Frohlich, Jacques Genest, Milan Gupta, Robert A Hegele, Dominic Ng, Glen J Pearson, Janet Pope, A Yashar Tashakkor
Journal	The Canadian journal of cardiology (Can J Cardiol) Vol. 32 Issue 7 Suppl Pg. S35-65 (07 2016) ISSN: 1916-7075 [Electronic] England
PMID	27342697 (Publication Type: Consensus Development Conference, Journal Article, Review, Research Support, Non-U.S. Gov't)
Copyright	Copyright © 2016 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
Chemical References	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Topics	Autoimmune Diseases (chemically induced, prevention & control) Cardiovascular Diseases (prevention & control) Cataract (chemically induced, prevention & control) Cognition Disorders (chemically induced, prevention & control) Diabetes Mellitus, Type 2 (chemically induced, prevention & control) Evidence-Based Medicine Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects, therapeutic use) Muscular Diseases (chemically induced, prevention & control) Risk Reduction Behavior

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