Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease.

Abstract

Intracellular trafficking events powered by microtubule-based molecular motors facilitate the targeted delivery of selected molecular components to specific neuronal subdomains. Within this context, we provide a brief review of mechanisms underlying the execution of axonal transport (AT) by conventional kinesin, the most abundant kinesin-related motor protein in the mature nervous system. We emphasize the biochemical heterogeneity of this multi-subunit motor protein, further discussing its significance in light of recent discoveries revealing its regulation by various protein kinases. In addition, we raise issues relevant to the mode of conventional kinesin attachment to cargoes and examine recent evidence linking alterations in conventional kinesin phosphorylation to the pathogenesis of adult-onset neurodegenerative diseases.

• Authors: Gerardo Morfini, Nadine Schmidt, Carina Weissmann, Gustavo Pigino, Stefan Kins
• Journal: Brain research bulletin (Brain Res Bull) Vol. 126 Issue Pt 3 Pg. 347-353 (09 2016) ISSN: 1873-2747 [Electronic] United States
• PMID: 27339812 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• Kinesins

Topics

• Animals
• Axonal Transport (physiology)
• Brain (metabolism)
• Humans
• Kinesins (chemistry, genetics, metabolism)
• Neurodegenerative Diseases (metabolism)