Abstract | BACKGROUND: METHOD: We randomly allocated consecutive patients undergoing major liver resection for hepatocellular carcinoma to either a group where oral BCAA administration was initiated 3 weeks before liver resection, or a non-BCAA group. The primary study endpoint was development of postoperative ascites. RESULTS: Overall, 39 patients were allocated to the BCAA group, while 38 were assigned to the non-BCAA group. No significant difference in the rate of refractory ascites, considered alone, was evident between the BCAA (5.1 %) and non-BCAA groups (13.2 %; p = 0.263). However, the occurrence of refractory ascites and/or pleural effusion was significantly less frequent in the BCAA group (5.1 %) than in the non-BCAA group (21.1 %; p = 0.047). Furthermore, the postoperative serum concentration of reduced-state albumin was greater immediately after liver resection in the BCAA group than in the non-BCAA group. CONCLUSION: Preoperative administration of BCAA did not significantly improve prevention of refractory ascites, but significant effectiveness in preventing ascites, pleural effusion, or both, as well as improving metabolism of albumin, was demonstrated [University Hospital Medical Information Network (UMIN) reference number 000004244].
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Authors | Yutaro Kikuchi, Yukihiko Hiroshima, Kenichi Matsuo, Daisuke Kawaguchi, Takashi Murakami, Yasuhiro Yabushita, Itaru Endo, Masataka Taguri, Keiji Koda, Kuniya Tanaka |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 23
Issue 11
Pg. 3727-3735
(10 2016)
ISSN: 1534-4681 [Electronic] United States |
PMID | 27338747
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amino Acids, Branched-Chain
- Serum Albumin
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Topics |
- Aged
- Aged, 80 and over
- Amino Acids, Branched-Chain
(therapeutic use)
- Ascites
(etiology, prevention & control)
- Carcinoma, Hepatocellular
(surgery)
- Female
- Hepatectomy
(adverse effects)
- Humans
- Liver Neoplasms
(surgery)
- Male
- Middle Aged
- Pleural Effusion
(etiology, prevention & control)
- Postoperative Complications
(etiology, prevention & control)
- Preoperative Care
- Serum Albumin
(drug effects, metabolism)
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