Sarcoma-like tumor originating from oligodendroglioma.

Abstract

We present a case of sarcoma occurring at a site of resected oligodendroglioma without preceding radiotherapy or chemotherapy. Oligosarcoma occurring at sites of resected oligodendroglioma or anaplastic oligodendroglioma with sarcomatous components are rare. Although meningioma or sarcoma-like lesions are sometimes reported after glioma-targeted radiotherapy, those without preceding radiotherapy are quite rare. Moreover, cases of sarcoma without oligodendroglial components occurring at a site of resected oligodendroglioma have never been reported. In this case, fluorescent in situ hybridization analysis revealed 1p/19q co-deletion in both the first tumor and second tumors. Additionally, immunohistochemistry revealed mutated isocitrate dehydrogenase 1 in both tumors. Taken together, these findings suggest a monoclonal tumor origin. Consequently, this case may indicate a new mechanism of development of sarcomatous lesions occurring at the site of a resected glioma.

• Authors: Takuhiro Shoji, Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga
• Journal: Brain tumor pathology (Brain Tumor Pathol) Vol. 33 Issue 4 Pg. 255-260 (Oct 2016) ISSN: 1861-387X [Electronic] Japan
• PMID: 27333891 (Publication Type: Case Reports, Journal Article)

Chemical References

• Isocitrate Dehydrogenase

Topics

• Adult
• Brain Neoplasms (diagnosis, genetics, pathology, surgery)
• Cell Transformation, Neoplastic
• Chromosomes, Human, Pair 1 (genetics)
• Chromosomes, Human, Pair 19 (genetics)
• Gene Deletion
• Humans
• Isocitrate Dehydrogenase (genetics)
• Magnetic Resonance Imaging
• Male
• Mutation
• Neoplasms, Multiple Primary
• Oligodendroglioma (diagnosis, genetics, pathology, surgery)
• Sarcoma (diagnosis, genetics, pathology, surgery)