Amphotericin B liposome-induced acrocyanosis and elevated serum creatinine.

Abstract

A 77-year-old male patient developed acrocyanosis and pain after treatment with amphotericin B liposome 150 mg daily intravenously for disseminated histoplasmosis, and subsequently developed elevated serum creatinine. Amphotericin B liposome was discontinued, and anisodamine was used intravenously to treat acrocyanosis and pain induced by amphotericin B liposome for 9 days and patient was cured. Naranjo adverse drug reaction probability scale score was 5, the World Health Organization-Uppsala Monitoring Centre criteria: Probable, indicating a probable adverse reaction to amphotericin B liposome.

• Authors: Xiangcai Zhang, Jie Jin, Chuang Cai, Ren Zheng, Yu Wang, Yingying Xu
• Journal: Indian journal of pharmacology (Indian J Pharmacol) 2016 May-Jun Vol. 48 Issue 3 Pg. 321-3 ISSN: 1998-3751 [Electronic] India
• PMID: 27298506 (Publication Type: Case Reports, Journal Article)

Chemical References

• Liposomes
• Amphotericin B
• Creatinine

Topics

• Aged
• Amphotericin B (administration & dosage)
• Creatinine (blood)
• Humans
• Liposomes
• Male