Abstract | OBJECTIVE: METHODS: In this pilot, randomized, double-blind, placebo-controlled trial, subjects who met the criteria of metabolic syndrome according to the National Cholesterol Education Program Adult Treatment Panel III criteria were randomly assigned to curcumin (n = 59; 1000 mg/d) or a placebo (n = 58) for 8 wk. Serum adiponectin and leptin concentrations were determined before and after intervention. The pooled effect size for the impact of curcumin supplementation on serum adiponectin and leptin levels was also estimated using random-effects metaanalysis. RESULTS: Eight-week supplementation with curcumin was associated with a significant increase in serum adiponectin levels (P < 0.001) and a reduction in serum leptin concentrations (P < 0.001). Serum leptin: adiponectin ratio was also improved by curcumin (P < 0.001). These beneficial effects of curcumin remained significant after adjustment for changes in serum lipids and glucose concentrations and baseline differences in body mass index and serum levels of glucose and glycated hemoglobin as potential confounders of treatment response. Metaanalysis suggested that curcumin supplementation can increase adiponectin levels by 76.78% (95% CI: 6.14-147.42; P = 0.0330), and reduce leptin by 26.49% (95% CI: -70.44 to 17.46), however this latter effect size did not reach statistical significance (P = 0.238). CONCLUSIONS:
Curcumin can improve serum levels of adiponectin and leptin in patients with metabolic syndrome. This trial was registered at the UMIN Clinical Trials Registry (http://www.umin.ac.jp/ctr/) under Trial No. UMIN000018339.
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Authors | Yunes Panahi, Mahboobeh Sadat Hosseini, Nahid Khalili, Effat Naimi, Sara Saffar Soflaei, Muhammed Majeed, Amirhossein Sahebkar |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
Vol. 32
Issue 10
Pg. 1116-22
(Oct 2016)
ISSN: 1873-1244 [Electronic] United States |
PMID | 27297718
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2016 Elsevier Inc. All rights reserved. |
Chemical References |
- ADIPOQ protein, human
- Adipokines
- Adiponectin
- Blood Glucose
- Leptin
- Lipids
- Curcumin
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Topics |
- Adipokines
(blood)
- Adiponectin
(blood)
- Adult
- Blood Glucose
(metabolism)
- Curcumin
(administration & dosage)
- Dietary Supplements
- Double-Blind Method
- Female
- Humans
- Insulin Resistance
- Leptin
(blood)
- Lipids
(blood)
- Male
- Metabolic Syndrome
(blood, diet therapy)
- Middle Aged
- Pilot Projects
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