Efficacy of Tamsulosin, Oxybutynin, and their combination in the control of double-j stent-related lower urinary tract symptoms.

Abstract

INTRODUCTION AND OBJECTIVE:

Indwelling double J ureteral stents are used routinely in the resolution of ureteral obstruction caused by different etiologies. Evaluation of urinary symptoms related to double-J stent, indicate that these affect 73-90% of patients. We conducted a prospective, randomized study, to evaluate the efficacy of tamsulosin, oxybutinin and combination therapy in improving the urinary symptoms.

METHODS:

Patients who underwent ureteral stent placement after ureterolithotripsy (total 51), were randomized into three groups: Group I: Tamsulosin 0.4 mg. Once per day(17 patients), Group II: Oxybutinin 5 mg. once per day (17 patients), Group III: Tamsulosin+ oxybutynin once per day (17 patients). All the groups received the drugs for three weeks and completed a Spanish validated Ureteral Stent Symptom Questionnaire (USSQ) at day 7 and 21.

RESULTS:

Repeated measures ANOVA showed mean urinary symptom index score was 22.3 vs. 15.5 in group three (p<0.001) at day 7 and 21 respectively. The mean work performance index was 6.6 vs 8.1 (p=0.049) favoring tamsulosin group, the mean sexual score was 0.5 vs 1.5 (p=0.03). Among additional problems the mean was 7.2 vs 6.2 (p=0.03). No significant difference was noted among pain and general health index. No side effects were reported.

CONCLUSIONS:

Combination therapy with tamsulosin and oxybutynin improved irritative symptoms and work performance as well as sexual matters. Combination therapy should be considered for patients who complained of stent related symptoms.

• Authors: Miguel Maldonado-Avila, Leopoldo Garduno-Arteaga, Rene Jungfermann-Guzman, Hugo A Manzanilla-Garcia, Emmanuel Rosas-Nava, Nestor Procuna-Hernandez, Alejandro Vela-Mollinedo, Luis Almazan-Trevino, Jose Guzman-Esquivel
• Journal: International braz j urol : official journal of the Brazilian Society of Urology (Int Braz J Urol) 2016 May-Jun Vol. 42 Issue 3 Pg. 487-93 ISSN: 1677-6119 [Electronic] Brazil
• PMID: 27286111 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Mandelic Acids
• Sulfonamides
• Urological Agents
• Tamsulosin
• oxybutynin

Topics

• Adult
• Analysis of Variance
• Drug Therapy, Combination
• Female
• Humans
• Lower Urinary Tract Symptoms (drug therapy, etiology, prevention & control)
• Male
• Mandelic Acids (therapeutic use)
• Middle Aged
• Prospective Studies
• Quality of Life
• Reproducibility of Results
• Single-Blind Method
• Stents (adverse effects)
• Sulfonamides (therapeutic use)
• Surveys and Questionnaires
• Tamsulosin
• Time Factors
• Treatment Outcome
• Ureter
• Ureteral Obstruction (complications, therapy)
• Ureteroscopy
• Urological Agents (therapeutic use)