Abstract |
Drug delivery system based on nanobiotechnology can improve the pharmacokinetics and therapeutic index of chemotherapeutic agents, which has revolutionized tumor therapy. Onivyde, also known as MM-398 or PEP02, is a nanoliposomal formulation of irinotecan which has demonstrated encouraging anticancer activity across a broad range of malignancies, including pancreatic cancer, esophago- gastric cancer, and colorectal cancer. This up-to-date review not only focuses on the structure, pharmacokinetics, and pharmacogenetics of Onivyde but also summarizes clinical trials and recommends Onivyde for patients with advanced solid tumors.
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Authors | Haijun Zhang |
Journal | OncoTargets and therapy
(Onco Targets Ther)
Vol. 9
Pg. 3001-7
( 2016)
ISSN: 1178-6930 [Print] New Zealand |
PMID | 27284250
(Publication Type: Journal Article, Review)
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