Abstract | BACKGROUND:
Proteins present in the latex of Calotropis procera have been shown to produce anti-inflammatory effect and to afford protection in various disease models. OBJECTIVES: MATERIALS AND METHODS: RESULTS:
Intra-articular injection of FCA produced joint swelling and difficulty in stair climbing ability, motility, and pain on flexion of the joint as revealed by scores obtained for these functional parameters. LPPI produced a dose-dependent decrease in joint swelling and improved joint functions. Arthritic rats also revealed altered oxidative homeostasis where joint tissue GSH levels were decreased and TBARS levels were increased as compared to normal rats. The levels of these oxidative stress markers were near normal in arthritic rats treated with LPPI. Moreover, treatment with LPPI also maintained the structural integrity of the joint. The protective effect of LPPI was comparable to the standard anti-inflammatory drug, diclofenac. CONCLUSION: The findings of the present study show that LPPI fraction comprising high molecular weight proteins could be used for the alleviation of arthritic symptoms. SUMMARY:
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Authors | Priyanka Chaudhary, Marcio V Ramos, Mirele da Silveira Vasconcelos, Vijay L Kumar |
Journal | Pharmacognosy magazine
(Pharmacogn Mag)
Vol. 12
Issue Suppl 2
Pg. S147-51
(May 2016)
ISSN: 0973-1296 [Print] India |
PMID | 27279699
(Publication Type: Journal Article)
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