Impaired HDL cholesterol efflux in metabolic syndrome is unrelated to glucose tolerance status: the CODAM study.

Abstract

Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) increase atherosclerotic cardiovascular disease risk. Cholesterol efflux capacity (CEC) is a key metric of the anti-atherosclerotic functionality of high-density lipoproteins (HDL). The present study aimed to delineate if T2DM and MetS cross-sectionally associate with altered CEC in a large high cardiometabolic risk population. CEC was determined from THP-1 macrophage foam cells towards apolipoprotein B-depleted plasma from 552 subjects of the CODAM cohort (288 controls, 126 impaired glucose metabolism [IGM], 138 T2DM). MetS was present in 297 participants. CEC was not different between different glucose tolerance categories but was lower in MetS (P < 0.001), at least partly attributable to lower HDL cholesterol (HDL-C) and apoA-I levels (P < 0.001 for each). Low grade inflammation was increased in IGM, T2DM and MetS as determined by a score comprising 8 different biomarkers (P < 0.05-< 0.001; n = 547). CEC inversely associated with low-grade inflammation taking account of HDL-C or apoA-I in MetS (P < 0.02), but not in subjects without MetS (interaction: P = 0.015). This study demonstrates that IGM and T2DM do not impact the HDL CEC function, while efflux is lower in MetS, partly dependent on plasma HDL-C levels. Enhanced low-grade inflammation in MetS may conceivably impair CEC even independent of HDL-C and apoA-I.

• Authors: Wijtske Annema, Arne Dikkers, Jan Freark de Boer, Marleen M J van Greevenbroek, Carla J H van der Kallen, Casper G Schalkwijk, Coen D A Stehouwer, Robin P F Dullaart, Uwe J F Tietge
• Journal: Scientific reports (Sci Rep) Vol. 6 Pg. 27367 (06 08 2016) ISSN: 2045-2322 [Electronic] England
• PMID: 27270665 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Apolipoprotein A-I
• Apolipoproteins B
• Glycated Hemoglobin A
• Lipoproteins, HDL
• Triglycerides
• hemoglobin A1c protein, human
• Cholesterol
• Glucose

Topics

• Apolipoprotein A-I (blood)
• Apolipoproteins B (blood)
• Biological Transport (physiology)
• Cholesterol (adverse effects, metabolism)
• Cohort Studies
• Diabetes Mellitus, Type 2 (pathology)
• Female
• Foam Cells (pathology)
• Glucose (metabolism)
• Glucose Intolerance (pathology)
• Glycated Hemoglobin (analysis)
• Humans
• Inflammation (pathology)
• Lipoproteins, HDL (blood)
• Male
• Metabolic Syndrome (pathology)
• Triglycerides (blood)