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Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia.

AuthorsB M Richine, E L Virts, J D Bowling, B Ramdas, R Mali, R Naoye, Z Liu, Z-Y Zhang, H S Boswell, R Kapur, R J Chan
JournalLeukemia (Leukemia) Vol. 30 Issue 10 Pg. 2094-2097 (10 2016) ISSN: 1476-5551 [Electronic] England
PMID27256702 (Publication Type: Letter, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Enzyme Inhibitors
  • STAT5 Transcription Factor
  • FLT3 protein, human
  • fms-Like Tyrosine Kinase 3
  • Syk Kinase
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11
Topics
  • Amino Acid Sequence
  • Cell Proliferation
  • Enzyme Inhibitors (pharmacology)
  • Humans
  • Leukemia, Myeloid, Acute (metabolism, pathology)
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11 (antagonists & inhibitors)
  • STAT5 Transcription Factor (metabolism)
  • Sequence Homology, Amino Acid
  • Syk Kinase (antagonists & inhibitors)
  • fms-Like Tyrosine Kinase 3 (chemistry, physiology)

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