HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis.

Abstract

BACKGROUND:

The HLA-DRB*1501 haplotype influences the risk of developing multiple sclerosis (MS), but it is not known how it affects grey matter pathology.

AIM:

To assess HLA-DRB(*)1501 effects on magnetic resonance imaging (MRI) cortical grey matter pathology.

METHODS:

Whole and lesional cortical grey matter volumes, lesional and normal-appearing grey matter magnetization transfer ratio were measured in 85 people with MS and 36 healthy control subjects. HLA-DRB(*)1501 haplotype was determined by genotyping (rs3135388).

RESULTS:

No significant differences were observed in MRI measures between the HLA-DRB(*)1501 subgroups.

CONCLUSIONS:

The HLA-DRB(*)1501 haplotype is not strongly associated with MRI-visible grey matter pathology.

• Authors: Özgür Yaldizli, Varun Sethi, Matteo Pardini, Carmen Tur, Kin Y Mok, Nils Muhlert, Zheng Liu, Rebecca S Samson, Claudia A M Wheeler-Kingshott, Tarek A Yousry, Henry Houlden, John Hardy, David H Miller, Declan T Chard
• Journal: Multiple sclerosis and related disorders (Mult Scler Relat Disord) Vol. 7 Pg. 47-52 (May 2016) ISSN: 2211-0356 [Electronic] Netherlands
• PMID: 27237756 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier B.V. All rights reserved.

Chemical References

• HLA-DRB1 Chains
• HLA-DRB1*15:01 antigen

Topics

• Adult
• Cerebral Cortex (diagnostic imaging)
• Disability Evaluation
• Female
• Genetic Predisposition to Disease
• Genotype
• Gray Matter (diagnostic imaging)
• HLA-DRB1 Chains (genetics)
• Haplotypes
• Humans
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Multiple Sclerosis (diagnostic imaging, genetics)
• Organ Size
• Polymorphism, Single Nucleotide
• Young Adult