Antibodies reacting to carbonic anhydrase isozymes (I and II) and albumin in sera from dogs.

Abstract

IgGs to carbonic anhydrase isozymes (CA-I and CA-II) and albumin were identified in dog serum. IgG titers were determined in the sera of asymptomatic dogs, and in dogs with atopic dermatitis, diarrhea and/or vomiting, diabetes and/or pancreatitis, kidney disease, hepatic disease, and thyroid gland disease, using ELISA. Low titres of IgG-reactive CA-I, CA-II, BSA, and CSA were found in the sera of healthy beagles. Compared with healthy beagles, there was a significant difference in the titers of antibodies against CA-I in asymptomatic dogs, dogs with diabetes and/or pancreatitis, or thyroid gland disease, or hepatic disease. Compared with healthy beagles, there was a significant difference in the antibody titer of anti-CA-II IgG in asymptomatic dogs and in those with hepatic disease. There was a significant difference in the antibody titer of anti-BSA IgG between healthy beagles and dogs with hepatic disease.

• Authors: Toshiho Nishita, Rui Miyazaki, Takae Miyazaki, Hideharu Ochiai, Kensuke Orito
• Journal: Research in veterinary science (Res Vet Sci) Vol. 106 Pg. 180-2 (Jun 2016) ISSN: 1532-2661 [Electronic] England
• PMID: 27234558 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier Ltd. All rights reserved.

Chemical References

• Albumins
• Immunoglobulin G
• Carbonic Anhydrase I
• Carbonic Anhydrase II

Topics

• Albumins (genetics, metabolism)
• Animals
• Autoimmunity
• Carbonic Anhydrase I (genetics, metabolism)
• Carbonic Anhydrase II (genetics, metabolism)
• Dog Diseases (genetics, immunology, metabolism)
• Dogs (genetics, immunology, metabolism)
• Enzyme-Linked Immunosorbent Assay (veterinary)
• Food Hypersensitivity (genetics, immunology, metabolism, veterinary)
• Immunoglobulin G (blood)
• Male