Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application.

Abstract

The aim of this study was to construct redox- and pH-responsive degradable manganese dioxide (MnO2) nanosheets for cancer theranostic application. The small MnO2 nanosheets were synthesized, and then functionalized by hyaluronic acid (HA), demonstrating excellent stability and tumor-targeting ability. Cisplatin (cis-diamminedichloroplatinum [CDDP]) was absorbed by the nanosheets through a physical action, which was designed as MnO2/HA/CDDP. The prepared MnO2/HA/CDDP formulation was able to efficiently deliver CDDP to tumor cells in vitro and in vivo, resulting in improved therapeutic efficiency. Subsequently, they were triggered by lower pH and higher level of reduced glutathione to generate Mn(2+), enabling magnetic resonance imaging. The smart multifunctional system combining efficient magnetic resonance imaging and chemotherapy has the potential to be used as a tumor-targeting theranostic nanomedicine.

• Authors: Yongwei Hao, Lei Wang, Bingxiang Zhang, Dong Li, Dehui Meng, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang, Yun Zhang
• Journal: International journal of nanomedicine (Int J Nanomedicine) Vol. 11 Pg. 1759-78 ( 2016) ISSN: 1178-2013 [Electronic] New Zealand
• PMID: 27199556 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Manganese Compounds
• Oxides
• Hyaluronic Acid
• Cisplatin
• manganese dioxide

Topics

• A549 Cells
• Animals
• Antineoplastic Agents (pharmacokinetics, pharmacology, therapeutic use)
• Apoptosis (drug effects)
• Cell Cycle (drug effects)
• Cisplatin (pharmacokinetics, pharmacology, therapeutic use)
• Drug Delivery Systems (methods)
• Drug Liberation
• Endocytosis (drug effects)
• Humans
• Hyaluronic Acid (chemistry)
• Hydrogen-Ion Concentration
• Intracellular Space (metabolism)
• Magnetic Resonance Imaging
• Manganese Compounds (chemical synthesis, chemistry)
• Mice
• Nanoparticles (chemistry, ultrastructure)
• Neoplasms (drug therapy)
• Oxidation-Reduction
• Oxides (chemical synthesis, chemistry)
• Spectroscopy, Near-Infrared
• Theranostic Nanomedicine (methods)