Gestational hypertension and chronic hypertension on the risk of diabetes among gestational diabetes women.

Abstract

AIMS:

We aimed to examine the association of gestational hypertension and chronic hypertension at the inter-conception examination with type 2 diabetes risk among women with a history of gestational diabetes.

METHODS:

We conducted a population-based study among 1261 women who had a history of gestational diabetes at 1-5years after delivery in Tianjin, China. Logistic regression or Cox regression was used to assess the associations of gestational hypertension and chronic hypertension at the inter-conception examination with pre-diabetes and type 2 diabetes risks.

RESULTS:

Gestational diabetic women who had a history of gestational hypertension but did not use antihypertensive drugs during pregnancy had a 3.94-fold higher risk (95% CI: 1.94-8.02) of developing type 2 diabetes compared with those who were normotensive in index pregnancy. Compared with gestational diabetic women who had normal blood pressure at the inter-conception examination, hypertensive women at the inter-conception examination were 3.38 times (95% CI: 1.66-6.87) and 2.97 times (95% CI: 1.75-5.05) more likely to develop diabetes and prediabetes, respectively. The odds ratios of type 2 diabetes and prediabetes associated with each 5mmHg increase in systolic blood pressure were 1.25 (95% CI: 1.03-1.51) and 1.20 (95% CI: 1.06-1.35). Each 5mmHg increase in diastolic blood pressure contributed to a 1.49-fold higher risk (95% CI: 1.18-1.88) for type 2 diabetes and a 1.42-fold higher risk (95% CI: 1.22-1.65) for prediabetes.

CONCLUSIONS:

For women with prior gestational diabetes, gestational hypertension and chronic hypertension at the inter-conception examination were risk factors for type 2 diabetes.

• Authors: Xiaojing Yuan, Huikun Liu, Leishen Wang, Shuang Zhang, Cuiping Zhang, Junhong Leng, Ling Dong, Li Lv, Fengjun Lv, Huiguang Tian, Lu Qi, Jaakko Tuomilehto, Gang Hu
• Journal: Journal of diabetes and its complications (J Diabetes Complications) 2016 Sep-Oct Vol. 30 Issue 7 Pg. 1269-74 ISSN: 1873-460X [Electronic] United States
• PMID: 27185731 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Topics

• Adult
• Blood Pressure
• China (epidemiology)
• Diabetes Mellitus, Type 2 (epidemiology)
• Diabetes, Gestational (epidemiology)
• Female
• Humans
• Hypertension (epidemiology)
• Hypertension, Pregnancy-Induced (epidemiology)
• Pregnancy
• Risk Factors