Serum 25-hydroxyvitamin D and insulin resistance in people at high risk of cardiovascular disease: a euglycaemic hyperinsulinaemic clamp study.

Abstract

CONTEXT:

In observational studies, low serum 25-hydroxyvitamin D (25-OHD) concentration is associated with an increased risk of type 2 diabetes mellitus (DM). Increasing serum 25-OHD may have beneficial effects on insulin resistance or beta-cell function. Cross-sectional studies utilizing suboptimal methods for assessment of insulin sensitivity and serum 25-OHD concentration provide conflicting results.

OBJECTIVE:

This study examined the relationship between serum 25-OHD concentration and insulin resistance in healthy overweight individuals at increased risk of cardiovascular disease, using optimal assessment techniques.

METHODS:

A total of 92 subjects (mean age 56·0, SD 6·0 years), who were healthy but overweight (mean body mass index 30·9, SD 2·3 kg/m(2) ), underwent assessments of insulin sensitivity (two-step euglycaemic hyperinsulinaemic clamp, HOMA2-IR), beta-cell function (HOMA2%B), serum 25-OHD concentration and body composition (DEXA).

RESULTS:

Mean total 25-OHD concentration was 32·2, range 21·8-46·6 nmol/l. No association was demonstrated between serum 25-OHD concentration and insulin resistance.

CONCLUSIONS:

In this study using optimal assessment techniques to measure 25-OHD concentration, insulin sensitivity and body composition, there was no association between serum 25-OHD concentration and insulin resistance in healthy, overweight individuals at high risk of developing cardiovascular disease. This study suggests the documented inverse association between serum 25-OHD concentration and risk of type 2 DM is not mediated by a relationship between serum 25-OHD concentration and insulin resistance.

• Authors: I R Wallace, M C McKinley, C T McEvoy, L L Hamill, C N Ennis, A McGinty, P M Bell, C C Patterson, J V Woodside, I S Young, S J Hunter
• Journal: Clinical endocrinology (Clin Endocrinol (Oxf)) Vol. 85 Issue 3 Pg. 386-92 (09 2016) ISSN: 1365-2265 [Electronic] England
• PMID: 27175553 (Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
• Copyright: © 2016 John Wiley & Sons Ltd.

Chemical References

• Vitamin D
• 25-hydroxyvitamin D

Topics

• Cardiovascular Diseases
• Cross-Sectional Studies
• Diabetes Mellitus, Type 2
• Humans
• Insulin Resistance
• Middle Aged
• Overweight
• Vitamin D (analogs & derivatives, blood)