[Remission of acquired hemophilia A following radiation therapy for esophageal cancer].

Abstract

Although acquired hemophilia A (AHA) often develops in patients with neoplasms, there are few reports on the efficacy of radiation therapy during the bleeding phase of AHA in the prior literature. We herein present a case of AHA experiencing remission soon after radiation therapy for esophageal cancer. A man in his seventies, who had a history of radical nephrectomy for left renal cell carcinoma, received a diagnosis of esophageal cancer. Three months later, he noticed a right thigh hematoma, and was transferred to our hospital. Laboratory data revealed a marked reduction of coagulation factor VIII (FVIII) activity at 0.9% and the inhibitor to FVIII was detected in his serum at 21.8 BU/ml. Under a diagnosis of AHA, the patient received high-dose oral prednisolone, which failed to achieve disease remission. He then underwent radiation therapy to eradicate the underlying esophageal cancer. Despite tapering of the prednisolone dosage, FVIII inhibitor declined to undetectable levels. In this case, radiation therapy for the underlying cancer was associated with achieving complete remission of AHA.

• Authors: Kunio Yanagisawa, Yoshiyuki Ogawa, Takeki Mitsui, Hiroyuki Noguchi, Hiroaki Shimizu, Takuma Ishizaki, Hiroshi Handa, Masahiro Ieko, Akitada Ichinose, Yoshihisa Nojima
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 57 Issue 4 Pg. 451-5 (Apr 2016) ISSN: 0485-1439 [Print] Japan
• PMID: 27169449 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Factor VIII

Topics

• Aged
• Esophageal Neoplasms (complications, radiotherapy)
• Factor VIII (metabolism)
• Hemophilia A (complications, drug therapy)
• Humans
• Male
• Remission Induction
• Tomography, X-Ray Computed
• Treatment Outcome