Colochirosides A₁, A₂, A₃, and D, Four Novel Sulfated Triterpene Glycosides from the Sea Cucumber Colochirus robustus (Cucumariidae, Dendrochirotida).

Abstract

Four new triterpene glycosides, colochirosides A₁ (1), A₂ (2), A₃ (3) and D (4), have been isolated from the sea cucumber Colochirus robustus (Cucumariidae, Dendrochirotida). Structures of the glycosides have been elucidated by 2D NMR spectroscopy and mass-spectrometry. Colochiroside D (4) has a new type of carbohydrate chain having the only sulfate group attached to C-6 of the third (glucose) monosaccharide residue. Cytotoxic activities of glycosides 1-4 against the ascite form of mouse Ehrlich carcinoma cells and hemolytic activity against mouse erythrocytes have been studied. Hemolytic activity of the glycosides was higher than cytotoxic. Glycosides 1, 3 and 4 demonstrated strong effects, whereas compound 2 showed only moderate activity.

• Authors: Alexandra S Silchenko, Anatoly I Kalinovsky, Sergey A Avilov, Pelageya V Andryjaschenko, Pavel S Dmitrenok, Vladimir I Kalinin, Ekaterina A Yurchenko, Igor Yu Dolmatov
• Journal: Natural product communications (Nat Prod Commun) Vol. 11 Issue 3 Pg. 381-7 (Mar 2016) ISSN: 1934-578X [Print] United States
• PMID: 27169187 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Glycosides
• Triterpenes

Topics

• Animals
• Antineoplastic Agents (chemistry, pharmacology)
• Cell Line, Tumor
• Glycosides (chemistry)
• Hemolysis (drug effects)
• Mice
• Molecular Structure
• Sea Cucumbers (chemistry)
• Triterpenes (chemistry)