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Non-Invasive Diagnosis of Portal Hypertensive Gastropathy: Quantitative Analysis of Microbubble-Induced Stomach Wall Enhancement.

Abstract
The aim of the study described here was to elucidate the efficacy of contrast-enhanced ultrasound (CEUS) prospectively as a tool in the diagnosis of portal hypertensive gastropathy (PHG). The peak enhancement time at the upper stomach wall (PT) and intensity ratio at the upper stomach/the spleen (IR) between pre- and peak enhancement were evaluated by CEUS with perflubutane microbubble agent in 56 patients, 42 with cirrhosis (16 with PHG) and 14 controls. The IR was higher in patients with PHG (1.21 ± 0.11) than in those without (0.91 ± 0.15, p < 0.05) and the controls (0.78 ± 0.11, p < 0.01), although PT did not differ between these groups. The area under the receiver operating characteristic curve for IR was 0.8199 in the presence of PHG, with the best cutoff value of 0.94, sensitivity 65.9%, specificity 72.6%, positive predictive value 62.2%, negative predictive value 73.1% and accuracy 70.4%. CEUS may have potential as a less invasive tool for diagnosis of PHG in patients with cirrhosis.
AuthorsSoichiro Kiyono, Hitoshi Maruyama, Kazufumi Kobayashi, Takayuki Kondo, Tadashi Sekimoto, Taro Shimada, Osamu Yokosuka, Tadashi Yamaguchi
JournalUltrasound in medicine & biology (Ultrasound Med Biol) Vol. 42 Issue 8 Pg. 1792-9 (08 2016) ISSN: 1879-291X [Electronic] England
PMID27166020 (Publication Type: Evaluation Study, Journal Article)
CopyrightCopyright © 2016 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Contrast Media
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Contrast Media
  • Evaluation Studies as Topic
  • Female
  • Humans
  • Hypertension, Portal (complications, diagnostic imaging, physiopathology)
  • Image Enhancement (methods)
  • Liver Cirrhosis (complications, diagnostic imaging, physiopathology)
  • Male
  • Microbubbles
  • Middle Aged
  • Portal Vein (diagnostic imaging, physiopathology)
  • Sensitivity and Specificity
  • Stomach (diagnostic imaging)

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