Abstract | CONTEXT: OBJECTIVE: We aimed at describing efficacy and tolerance for a topical formulation of STS in treated patients. DESIGN: We performed a retrospective study wherein clinical, radiological, and biological data before and after the application of the topical STS treatment were collected and analyzed. PATIENTS OR OTHER PARTICIPANTS: Three patients admitted to 3 different hospitals with an ectopic calcification secondary to HFTC or HHS were treated with topical STS. INTERVENTION: The topical STS was applied daily by the patients. RESULTS: A significant clinical and radiological decrease of ectopic calcifications was observed after at least 5 months of treatment. The STS treatment was well tolerated and no clinical or biological side effects were observed. CONCLUSION: Topical STS appears to be a promising treatment for ectopic calcifications secondary to HFTC or HHS.
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Authors | Jérémy Jost, Claire Bahans, Marie Courbebaisse, Tu-Anh Tran, Agnès Linglart, Karelle Benistan, Anne Lienhardt, Hadile Mutar, Elodie Pfender, Voa Ratsimbazafy, Vincent Guigonis |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 101
Issue 7
Pg. 2810-5
(07 2016)
ISSN: 1945-7197 [Electronic] United States |
PMID | 27163355
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Thiosulfates
- sodium thiosulfate
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Topics |
- Administration, Topical
- Adult
- Calcinosis
(diagnosis, drug therapy)
- Child
- Female
- Humans
- Hyperostosis, Cortical, Congenital
(diagnosis, drug therapy)
- Hyperphosphatemia
(diagnosis, drug therapy)
- Male
- Prognosis
- Retrospective Studies
- Thiosulfates
(administration & dosage, adverse effects)
- Treatment Outcome
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