Inflammation-based prognostic system predicts postoperative survival of esophageal carcinoma patients with normal preoperative serum carcinoembryonic antigen and squamous cell carcinoma antigen levels.

Abstract

BACKGROUND:

The Glasgow Prognostic Score (GPS) is an established inflammation-based system that is used to predict the prognosis for several types of malignancies. In this retrospective study, we assessed the postoperative survival of 725 patients with non-metastatic esophageal squamous cell carcinoma who had normal preoperative serum tumor marker levels according to the GPS.

METHODS:

Among 1394 patients who underwent esophagectomy between August 2006 and December 2010, 725 with normal preoperative serum levels of carcinoembryonic antigen (CEA) and squamous cell carcinoma antigen (SCC-Ag) were enrolled. All demographic, pathologic, and survival data were analyzed retrospectively. Uni- and multivariate analyses were performed to evaluate the relationship with overall survival. The Kaplan-Meier analysis and log-rank tests were used to compare the survival curves between patients with GPS 0 (group A) and 1 or 2 (group B).

RESULTS:

Patients in group A exhibited significantly better 3- and 5-year cancer-specific survival (CSS) rates (0.780 and 0.759, respectively) than those in group B (0.624 and 0.605, respectively). Multivariate Cox regression analysis revealed that age, tumor length, pathological tumor-node-metastasis (pTNM) stage, venous invasion, lymph node metastasis, serum albumin and C-reactive protein levels, and GPS were associated with postoperative survival of these patients. Further multivariate analysis confirmed that GPS was an independent prognostic factor. The Kaplan-Meier analysis and log-rank tests demonstrated a significant difference in CSS between groups A and B (P = 0.001).

CONCLUSIONS:

GPS may be a valuable prognostic indicator for esophageal cancer patients with normal preoperative CEA and SCC-Ag serum levels.

• Authors: Qilong Ma, Wengao Liu, Ran Jia, Feng Jiang, Hao Duan, Peng Lin, Lanjun Zhang, Hao Long, Hongyun Zhao, Guowei Ma
• Journal: World journal of surgical oncology (World J Surg Oncol) Vol. 14 Pg. 141 (May 05 2016) ISSN: 1477-7819 [Electronic] England
• PMID: 27151090 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Neoplasm
• Biomarkers, Tumor
• Carcinoembryonic Antigen
• Serpins
• squamous cell carcinoma-related antigen
• C-Reactive Protein

Topics

• Adult
• Aged
• Aged, 80 and over
• Antigens, Neoplasm (blood)
• Biomarkers, Tumor (blood)
• C-Reactive Protein (analysis)
• Carcinoembryonic Antigen (blood)
• Carcinoma, Squamous Cell (blood, mortality, surgery)
• Esophageal Neoplasms (blood, mortality, surgery)
• Esophagectomy (mortality)
• Female
• Follow-Up Studies
• Humans
• Inflammation (blood, pathology)
• Male
• Middle Aged
• Neoplasm Staging
• Postoperative Period
• Prognosis
• Retrospective Studies
• Serpins (blood)
• Severity of Illness Index
• Survival Rate