Two Elderly Patients with Philadelphia Chromosome Positive Mixed Phenotype Acute Leukemia Who Were Successfully Treated with Dasatinib and Prednisolone.

Abstract

Philadelphia chromosome positive (Ph+) mixed phenotype acute leukemia (MPAL) is a rare type of acute leukemia having both myeloid and lymphoid features for which no optimal treatment has yet been established. We herein describe two elderly Ph+MPAL patients who achieved molecular remission without any serious adverse events by treatment with dasatinib and prednisolone. Although dasatinib induction therapy combined with prednisolone is known to be a highly effective treatment for Ph+ acute lymphoblastic leukemia, its efficacy for Ph+MPAL has not been shown. The clinical courses of the present cases suggest that combination therapy with dasatinib and prednisolone is a safe and effective therapeutic modality in elderly Ph+MPAL patients.

• Authors: Hiroyuki Takata, Taichi Ikebe, Hitohiro Sasaki, Yasuhiko Miyazaki, Eiichi Ohtsuka, Yoshio Saburi, Masao Ogata, Kuniaki Shirao
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 55 Issue 9 Pg. 1177-81 ( 2016) ISSN: 1349-7235 [Electronic] Japan
• PMID: 27150875 (Publication Type: Case Reports, Journal Article)

Chemical References

• Prednisolone
• Dasatinib

Topics

• Acute Disease
• Aged
• Dasatinib (administration & dosage, therapeutic use)
• Drug Therapy, Combination
• Female
• Humans
• Phenotype
• Philadelphia Chromosome
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (drug therapy, genetics)
• Prednisolone (administration & dosage, therapeutic use)
• Treatment Outcome