Abstract | INTRODUCTION: AIM: To evaluate correlation of IMA with glycaemic control in type 2 DM (T2DM). Secondary aim was to assess the utility of IMA as a marker for vascular complications in T2DM. MATERIALS AND METHODS: During this cross-sectional study, a total of 100 diagnosed cases of T2DM were recruited between May 2013 and September 2013. The IMA, HbA1c, lipid profile, creatinine and urine micro- albumin levels were measured and analysed with respect to clinical condition of the patients. STATISTICAL ANALYSIS: The epidemiological software, Epi-Info 7.1.5, was used for the statistical analysis, p-value<0.05 was defined as level of significance. RESULTS: The study subjects were in the age group from 30 to 75 years and 52.4% were males. There was a great degree of variance in the level of glycaemic control and majority (64.6%) had poor or very poor glycaemic control as reflected by their HbA1c levels. The IMA (Mean ± SEM) levels were found to be higher (62.9 ± 1.7ABSU) in the patients with poor glycaemic control compared to those with good glycaemic control (54.2 ± 3.5 ABSU, p-value < 0.05) and correlated with HbA1c levels (r(2)=0.14). IMA levels also appeared to be related with the changes in lipid profile and increased with increasing total cholesterol levels. The subjects with macro-vascular complications (retinopathy and neuropathy) showed non-significantly higher levels of IMA. The elevation in IMA correlated with the HbA1c and changes in the lipid profile. CONCLUSION: IMA correlates with poor glycaemic control and dyslipidaemia associated with T2 DM and could serve as an indicator of oxidant stress in these patients.
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Authors | Rajinder Chawla, Rinchu Loomba, Deepak Guru, Vikas Loomba |
Journal | Journal of clinical and diagnostic research : JCDR
(J Clin Diagn Res)
Vol. 10
Issue 3
Pg. BC13-6
(Mar 2016)
ISSN: 2249-782X [Print] India |
PMID | 27134857
(Publication Type: Journal Article)
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