External Application of Apo-9'-fucoxanthinone, Isolated from Sargassum muticum, Suppresses Inflammatory Responses in a Mouse Model of Atopic Dermatitis.

Abstract

Allergic skin inflammation such as atopic dermatitis is characterized by skin barrier dysfunction, edema, and infiltration with various inflammatory cells. The anti-inflammatory effects of Apo-9'-fucoxanthinone, isolated from Sargassum muticum, have been described in many diseases, but the mechanism by which it modulates the immune system is poorly understood. In this study, the ability of Apo-9'-fucoxanthinone to suppress allergic reactions was investigated using a mouse model of atopic dermatitis. The Apo-9'-fucoxanthinone-treated group showed significantly decreased immunoglobulin E in serum. Also, Apo-9'-fucoxanthinone treatment resulted in a smaller lymph node size with reduced the thickness and length compared to the induction group. In addition, Apo-9'-fucoxanthinone inhibited the expression of interleukin-4, interferon-gamma and tumor necrosis factor-alpha by phorbol 12-myristate 13-acetate and ionomycin-stimulated lymphocytes. These results suggest that Apo-9'-fucoxanthinone may be a useful therapeutic strategy for treating chronic inflammatory diseases.

• Authors: Sang-Chul Han, Na-Jin Kang, Weon-Jong Yoon, Sejin Kim, Min-Chull Na, Young-Sang Koh, Jin-Won Hyun, Nam-Ho Lee, Mi-Hee Ko, Hee-Kyoung Kang, Eun-Sook Yoo
• Journal: Toxicological research (Toxicol Res) Vol. 32 Issue 2 Pg. 109-14 (Apr 2016) ISSN: 1976-8257 [Print] Singapore
• PMID: 27123161 (Publication Type: Journal Article)