Effects of Coronary Arterial Injection of Tirofiban on Diabetes Mellitus Complicated with Acute Myocardial Infarction in the Elderly.

Abstract

OBJECTIVE:

This work aims to explore the short-term efficacy and safety of coronary arterial injection of tirofiban in elderly diabetic patients complicated with acute myocardial infarction (AMI) who underwent emergency percutaneous coronary intervention (PCI).

METHODS:

Ninety-seven elderly diabetic patients complicated with ST-elevation myocardial infarction (STEMI) who underwent emergency PCI were selected and randomized into control (group A, 49 cases) and tirofiban (group B, 48 cases) groups. Another 129 nonelderly diabetic patients (group C) complicated with STEMI who underwent emergency PCI and tirofiban treatment in the corresponding period were also involved for comparison.

RESULTS:

Thrombolysis in myocardial infarction 3 (TIMI3) flow was significantly higher in groups B and C than in group A after PCI (p < 0.01). TIMI myocardial perfusion grades (TMPG) 0 to 1 and 2 were distinctly lower (p < 0.01, p < 0.05) and TMPG3 was obviously higher (p < 0.01) in groups B and C than in group A. The average length of hospital stay, post-infarction angina pectoris, severe arrhythmia, and cardiac function Killip III to IV were markedly lower in groups B and C than in group A (p < 0.01, p < 0.05). Meanwhile, mucocutaneous hemorrhage was significantly higher in groups B and C than in group A (p < 0.01).

CONCLUSIONS:

Tirofiban effectively improved TIMI flow and TMPG perfusion in elderly diabetic patients complicated with AMI and reduced the incidence of serious complications without increasing the occurrence of severe hemorrhage.

KEY WORDS:

Acute myocardial infarction; Diabetes mellitus; Emergency percutaneous coronary intervention; Tirofiban.

• Authors: Yang Liu, Heng-Liang Liu, Guo-Ying Geng, Ning Ba, Song-Bin Jing, Wei Guo, Zhi-Fang Zhang
• Journal: Acta Cardiologica Sinica (Acta Cardiol Sin) Vol. 29 Issue 6 Pg. 550-6 (Nov 2013) ISSN: 1011-6842 [Print] China (Republic : 1949- )
• PMID: 27122756 (Publication Type: Journal Article)