Choline supplementation alters some amino acid concentrations with no change in homocysteine in children with cystic fibrosis and pancreatic insufficiency.

Abstract

The present study determined the plasma amino acid status in children with cystic fibrosis (CF) and pancreatic insufficiency (PI) in the modern medical and nutritional care setting and investigated the effect of choline supplementation on amino acid status. A total of 110 children aged 5 to 18 years with CF and PI were randomized to receive choline-enriched structured lipid (LYM-X-SORB) or placebo with similar energy and fat content. Plasma amino acids were measured at baseline and 3 and 12 months. We hypothesized that choline supplementation would result in lower plasma homocysteine concentrations in children with CF. At baseline, dietary protein intake was high and the amino acid profile was within laboratory reference ranges in most participants. Alanine and cysteine were elevated in 24% and 36% of participants, respectively. Children with baseline alanine above reference range had improved weight, body mass index, and fat-free mass. Low homocysteine was found in 62% of children 11 years and older. After 3 and 12 months, there was no effect of choline supplementation on methionine or homocysteine status. Compared with placebo, choline supplementation resulted in increased glycine and decreased threonine, histidine, valine, and total branch chained amino acids at 12 months. In conclusion, daily choline supplementation with LYM-X-SORB did not alter methionine-homocysteine metabolism but did result in alterations in other amino acids in children with CF and PI.

• Authors: Belal Alshaikh, Joan I Schall, Asim Maqbool, Maria Mascarenhas, Michael J Bennett, Virginia A Stallings
• Journal: Nutrition research (New York, N.Y.) (Nutr Res) Vol. 36 Issue 5 Pg. 418-29 (May 2016) ISSN: 1879-0739 [Electronic] United States
• PMID: 27101760 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• Amino Acids
• Amino Acids, Branched-Chain
• Placebos
• Homocysteine
• Methionine
• Choline

Topics

• Adolescent
• Amino Acids (blood)
• Amino Acids, Branched-Chain (blood)
• Child
• Child, Preschool
• Choline (administration & dosage)
• Cystic Fibrosis (blood, complications)
• Dietary Supplements
• Exocrine Pancreatic Insufficiency (blood, complications)
• Female
• Homocysteine (blood)
• Humans
• Male
• Methionine (blood)
• Placebos