Abstract | BACKGROUNDS: METHODS: Through the nationwide registry of the Korean Society of Spondyloarthritis Research, 3929 AS patients who were prescribed TNF inhibitors were recruited between June 2003 and June 2014 at fourteen referral hospitals. Clinical information was analyzed about the patients who experienced tuberculosis after exposure to TNF inhibitors. The clinical features of resumers and non-resumers of TNF inhibitors were compared and the outcomes of tuberculosis were surveyed individually. FINDINGS: Fifty-six AS patients were treated for tuberculosis associated with TNF inhibitors. Among them, 23 patients resumed TNF inhibitors, and these patients were found to be exposed to TNF inhibitors for a longer period of time and experienced more frequent disease flare-up after discontinuation of TNF inhibitors compared with those who did not resume. Fifteen patients resumed TNF inhibitors during anti- tuberculosis treatment (early resumers) and 8 after completion of anti- tuberculosis treatment (late resumers). Median time to resuming TNF inhibitor from tuberculosis was 3.3 and 9.0 months in the early and late resumers, respectively. Tuberculosis was treated successfully in all resumers and did not relapse in any of them during follow-up (median 33.8 [IQR; 20.8-66.7] months). CONCLUSIONS:
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Authors | Hye Won Kim, Seong Ryul Kwon, Kyong-Hee Jung, Seong-Kyu Kim, Han Joo Baek, Mi Ryung Seo, So-Young Bang, Hye-Soon Lee, Chang-Hee Suh, Ju Yang Jung, Chang-Nam Son, Seung Cheol Shim, Sang-Hoon Lee, Seung-Geun Lee, Yeon-Ah Lee, Eun Young Lee, Tae-Hwan Kim, Yong-Gil Kim, Korean Society of Spondyloarthritis Research |
Journal | PloS one
(PLoS One)
Vol. 11
Issue 4
Pg. e0153816
( 2016)
ISSN: 1932-6203 [Electronic] United States |
PMID | 27101309
(Publication Type: Journal Article)
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Chemical References |
- Tumor Necrosis Factor-alpha
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Topics |
- Adult
- Female
- Humans
- Male
- Middle Aged
- Republic of Korea
- Retrospective Studies
- Spondylitis, Ankylosing
(complications, drug therapy)
- Tuberculosis
(complications)
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
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