Improved Diagnosis of the Polysensitized Allergic Rhinitis Patients Using Component Resolved Diagnosis Method.

Abstract

Allergy diagnosis needs to be improved in polysensitized patients due to the existence of possible confounding factors in this type of patients. Component resolved diagnosis (CRD) is a new concept in the investigation of polysensitized patients. The aim of this study was to evaluate if the utilization of ImmunoCAP ISAC improve the diagnosis of the polysensitized allergic rhinitis patients. Skin prick test (SPT) to 58 crude allergen extracts and CRD (ImmunoCAP ISAC) were carried out for 5 polysensitized allergic rhinitis patients. Two patients had a shellfish allergy and avoidance of shellfish was the only way to prevent an allergic reaction. In contrast, although the remaining three patients had low risk for shellfish allergy, but they were the best candidates for immunotherapy using mite extracts. CRD and particularly ImmunoCAP ISAC have proven to be a valuable diagnostic tool in polysensitized patients. ImmunoCAP ISAC helps refine the individual patient's sensitization profile and predict the potential risk of allergic reactions and improve the selection of patients for immunotherapy.

• Authors: Zailatul Hani Mohamad Yadzir, Faizal Bakhtiar, Rosmilah Misnan, Noormalin Abdullah, Brenda Leecyous, Shahnaz Murad
• Journal: Iranian journal of allergy, asthma, and immunology (Iran J Allergy Asthma Immunol) Vol. 15 Issue 2 Pg. 156-60 (Apr 2016) ISSN: 1735-1502 [Print] Iran
• PMID: 27090369 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Allergens
• Complex Mixtures

Topics

• Adult
• Allergens (administration & dosage, immunology)
• Complex Mixtures (administration & dosage, immunology)
• Female
• Humans
• Male
• Rhinitis, Allergic (diagnosis, immunology)
• Shellfish
• Shellfish Hypersensitivity (diagnosis, immunology)
• Skin Tests (methods)