Effects of pretreatment with different doses of cisatracurium on succinylcholine-induced fasciculations.

Abstract

OBJECTIVE:

To compare the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations.

METHODS:

90 patients scheduled for laparoscopic cholecystectomies were equally randomized into three groups to receive pretreatment of 0.005, 0.01, and 0.02 mg/kg cisatracurium, respectively. After the pretreatments, general anesthesia was induced 3.5 minutes later, train-of-four stimulation was monitored 4.5 minutes later, succinylcholine 1.5 mg/kg was injected 5 minutes later, and endotracheal intubation was implemented 6.5 minutes later. Side effects of cisatracurium, intensity of fasciculations, intubating conditions, time and extent to maximal depression of twitch and time for its recovery to 20% of control value, and severity of myalgia at 24 hours postoperatively were recorded.

RESULTS:

Fasciculations were alleviated significantly after the cisatracurium pretreatment of 0.02 mg/kg, more than with the other two doses (p < 0.01). Intubating conditions, time and extent to maximal depression of twitch, time for its recovery to 20% of the controls, and incidence of myalgia had no significant changes among the three groups (p > 0.05). Transient and tolerable diplopia and difficulty opening eyes emerged after pretreatment of 0.02 mg/kg cisatracurium.

CONCLUSION:

The pretreatment of 0.02 mg/kg cisatracurium given 5 minutes before succinylcholine injection could alleviate succinylcholine-induced fasciculations without influence on muscle relaxation effects or endotracheal intubating conditions, but did not affect the occurrence of myalgia, and might produce transient diplopia and difficulty opening eyes.

• Authors: Zhuan Zhang, Dong-sheng Zhang, Wei Sui, Xu-hong Liu, Luo Zhang, Jian-hong Sun
• Journal: International journal of clinical pharmacology and therapeutics (Int J Clin Pharmacol Ther) Vol. 54 Issue 6 Pg. 426-32 (Jun 2016) ISSN: 0946-1965 [Print] Germany
• PMID: 27087153 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Neuromuscular Blocking Agents
• Atracurium
• Succinylcholine
• cisatracurium

Topics

• Adult
• Aged
• Atracurium (analogs & derivatives, pharmacology)
• Dose-Response Relationship, Drug
• Double-Blind Method
• Fasciculation (chemically induced, prevention & control)
• Female
• Humans
• Male
• Middle Aged
• Neuromuscular Blocking Agents (pharmacology)
• Succinylcholine (adverse effects)