Outcomes of MYC-associated lymphomas after R-CHOP with and without consolidative autologous stem cell transplant: subset analysis of randomized trial intergroup SWOG S9704.

Abstract	Double hit lymphoma (DHL) and double protein-expressing (MYC, BCL2) lymphomas (DPL) fare poorly with R-CHOP (rituximab + cyclophosphamide, doxorubicin, vincristine, prednisolone); consolidative autologous stem cell transplant (ASCT) may improve outcomes. S9704, a phase III randomized study of CHOP +/-R with or without ASCT enabled evaluation of intensive consolidation. Immunohistochemistry (IHC) identified 27 of 198 patients (13·6%) with MYC overexpression; 20 (74%) harboured concurrent BCL2 overexpression. Four had DHL and 16 had DPL only. With median 127 months follow-up, there is a trend favouring outcomes after ASCT in DPL and MYC protein overexpressing patients, whereas all DHL patients have died irrespective of ASCT.
Authors	Soham D Puvvada, Patrick J Stiff, Michael Leblanc, James R Cook, Stephen Couban, John P Leonard, Brad Kahl, Deborah Marcellus, Thomas C Shea, Jane N Winter, Hongli Li, Lisa M Rimsza, Jonathan W Friedberg, Sonali M Smith
Journal	British journal of haematology (Br J Haematol) Vol. 174 Issue 5 Pg. 686-91 (Sep 2016) ISSN: 1365-2141 [Electronic] England
PMID	27072903 (Publication Type: Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial)
Copyright	© 2016 John Wiley & Sons Ltd.
Chemical References	Antibodies, Monoclonal, Murine-Derived Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-myc R-CHOP protocol Rituximab Vincristine Doxorubicin Cyclophosphamide Prednisone
Topics	Adolescent Adult Aged Antibodies, Monoclonal, Murine-Derived (administration & dosage) Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use) Autografts Combined Modality Therapy (methods) Cyclophosphamide (administration & dosage) Doxorubicin (administration & dosage) Female Hematopoietic Stem Cell Transplantation (methods) Humans Lymphoma (mortality, therapy) Male Middle Aged Prednisone (administration & dosage) Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-myc Rituximab Treatment Outcome Vincristine (administration & dosage) Young Adult

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