Abstract | BACKGROUND: OBJECTIVE: METHODS: We relied on 634 PD patients and 879 controls to examine gene-PD susceptibility associations, and nested longitudinal cohort of 246 patients from the case-control study, which followed patients on average 5 years and 7.5 years into disease. We repeatedly assessed cognitive symptom progression with the MMSE and conducted a full neuropsychological battery on a subset of 183 cognitively normal patients. We used repeated-measures regression analyses to assess longitudinal associations between genotypes and cognitive progression scores. RESULTS: The MAPT H1 haplotype was associated with PD susceptibility. APOE 4 carriers (ɛ4+) (p = 0.03) and possibly COMT Met/Met (p = 0.06) carriers exhibited faster annual decline on the MMSE. Additionally, APOEɛ4+ carriers showed faster decline in many of the neuropsychological test scores. No such differences in neuropsychological outcomes were seen for the COMT genotypes. CONCLUSION:
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Authors | Kimberly C Paul, Rebecca Rausch, Michelle M Creek, Janet S Sinsheimer, Jeff M Bronstein, Yvette Bordelon, Beate Ritz |
Journal | Journal of Parkinson's disease
(J Parkinsons Dis)
Vol. 6
Issue 2
Pg. 349-59
(04 02 2016)
ISSN: 1877-718X [Electronic] Netherlands |
PMID | 27061069
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't)
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Chemical References |
- ApoE protein, human
- Apolipoproteins E
- MAPT protein, human
- tau Proteins
- COMT protein, human
- Catechol O-Methyltransferase
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Topics |
- Aged
- Apolipoproteins E
(genetics)
- Catechol O-Methyltransferase
(genetics)
- Cognition
- Disease Progression
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Middle Aged
- Parkinson Disease
(genetics, psychology)
- Polymorphism, Single Nucleotide
- tau Proteins
(genetics)
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