Collagenase Clostridium histolyticum: emerging practice patterns and treatment advances.

Abstract

OBJECTIVE:

This study aims to provide a comprehensive review of the role of Collagenase Clostridium histolyticum (CCH).

METHODS:

This review is based on a literature review and practical experience.

RESULTS:

This review provides practical management strategies for using collagenase by sharing clinical experiences over the past few years; logistical aspects of in-clinic treatment, lessons learned, and novel approaches to correct traditionally hard-to-treat contractures are discussed. In addition a brief, yet comprehensive overview is provided on the pathophysiology of the disease, the mechanism of collagenase action and results of clinical studies.

CONCLUSION:

CCH has an evolving role as one of the tools available for treating Dupuytren's disease.

• Authors: David Warwick, José M Arandes-Renú, Giorgio Pajardi, Jörg Witthaut, Lawrence C Hurst
• Journal: Journal of plastic surgery and hand surgery (J Plast Surg Hand Surg) Vol. 50 Issue 5 Pg. 251-61 (Oct 2016) ISSN: 2000-6764 [Electronic] Sweden
• PMID: 27050718 (Publication Type: Journal Article, Review)

Chemical References

• Microbial Collagenase

Topics

• Clinical Trials as Topic
• Comorbidity
• Dose-Response Relationship, Drug
• Dupuytren Contracture (drug therapy)
• Exercise Therapy
• Humans
• Injections, Intralesional
• Microbial Collagenase (therapeutic use)
• Recurrence
• Splints