Mechanisms of pentazocine-induced ventilatory depression and antinociception in anesthetized rats.

Abstract

This study was performed to clarify mechanisms underlying pentazocine-induced ventilatory depression and antinociception. Spontaneous ventilation and hind leg withdrawal response against nociceptive thermal stimulation were simultaneously recorded in anesthetized rats. Pentazocine decreased minute volume resulting from depression of the ventilatory rate and tracheal airflow, and prolonged the latency of withdrawal response. Pre-treatment of β-funaltorexamine, but not nor-binaltorphimine, significantly attenuated pentazocine-induced ventilatory depression, while either antagonist weakened its analgesic potency. Comparing with effects of fentanyl and U50488, the present results suggest that ventilatory depression induced by pentazocine is mediated by mainly μ receptors and analgesia by both μ and κ receptors.

• Authors: Satoko Kimura, Yoshiaki Ohi, Akira Haji
• Journal: Journal of pharmacological sciences (J Pharmacol Sci) Vol. 130 Issue 3 Pg. 181-4 (Mar 2016) ISSN: 1347-8648 [Electronic] Japan
• PMID: 27021234 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Japanese Pharmacological Society. Production and hosting by Elsevier B.V. All rights reserved.

Chemical References

• Analgesics
• Receptors, Opioid, kappa
• Receptors, Opioid, mu
• binaltorphimine
• Naltrexone
• beta-funaltrexamine
• Pentazocine

Topics

• Analgesics
• Anesthesia
• Animals
• Male
• Naltrexone (analogs & derivatives, pharmacology, therapeutic use)
• Pentazocine (adverse effects, pharmacology)
• Rats, Wistar
• Receptors, Opioid, kappa (physiology)
• Receptors, Opioid, mu (physiology)
• Respiratory Insufficiency (chemically induced, drug therapy)