Different cutaneous innate immunity profiles in acne patients with and without atrophic scars.

Abstract

BACKGROUND:

Acne is a chronic inflammatory disease associated with scar development in many patients.

OBJECTIVES:

To check whether early inflammatory events in the epidermis via keratinocytes influence the development of scars in acne patients.

METHODS:

We investigated several immunological markers involved in epidermal innate immunity in both clinically normal skin and inflammatory early papules in acne patients prone to scars or not.

RESULTS:

In normal skin of acne patients prone to scars vs not prone to scars, TLR-4, IL-2, IL-10, TIMP-2 and JUN were significantly overexpressed and the MMP-9 protein level was decreased. Similar results were obtained in early inflammatory papules (no more than three days), except for TLR-4.

CONCLUSION:

These results suggest for the first time a link between the early events of inflammation with levels of activation of innate immunity in normal epidermis of acne patients and the development of scars. These markers could be a target for drugs in the field of scar prevention.

• Authors: Mélanie Saint-Jean, Amir Khammari, Fiona Jasson, Jean-Michel Nguyen, Brigitte Dréno
• Journal: European journal of dermatology : EJD (Eur J Dermatol) 2016 Jan-Feb Vol. 26 Issue 1 Pg. 68-74 ISSN: 1952-4013 [Electronic] France
• PMID: 27018005 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Cytokines
• Toll-Like Receptor 2

Topics

• Acne Vulgaris (immunology, metabolism, pathology)
• Adolescent
• Adult
• Biomarkers (metabolism)
• Cicatrix (immunology, metabolism, pathology)
• Cytokines (metabolism)
• Epidermis (immunology, metabolism)
• Female
• Humans
• Immunity, Innate
• Keratinocytes (immunology, metabolism)
• Male
• Skin (immunology, metabolism, pathology)
• Toll-Like Receptor 2 (metabolism)
• Young Adult