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Acute Cryptococcal Immune Reconstitution Inflammatory Syndrome in a Patient on Natalizumab.

Abstract
Presented is the first case of acute immune reconstitution inflammatory syndrome (IRIS)-associated cryptococcal meningoencephalitis in a patient on natalizumab for multiple sclerosis. The patient developed acute cerebral edema after initiation of amphotericin B. We propose several mechanisms that explain the acuity of IRIS in this specific patient population and suggest possible therapies.
AuthorsNathan D Gundacker, Stephen J Jordan, Benjamin A Jones, Joseph C Drwiega, Peter G Pappas
JournalOpen forum infectious diseases (Open Forum Infect Dis) Vol. 3 Issue 1 Pg. ofw038 (Jan 2016) ISSN: 2328-8957 [Print] United States
PMID27006962 (Publication Type: Journal Article)

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