Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer.

Abstract

Herein, we present a study focused on the determination of the influence of long-distance (53 km) bicycle riding on levels of chosen biochemical urinary and serum prostate cancer (PCa) biomarkers total prostate-specific antigen (tPSA), free PSA (fPSA) and sarcosine. Fourteen healthy participants with no evidence of prostate diseases, in the age range from 49-57 years with a median of 52 years, underwent physical exercise (mean race time of 150 ± 20 min, elevation increase of 472 m) and pre- and post-ride blood/urine sampling. It was found that bicycle riding resulted in elevated serum uric acid (p = 0.001, median 271.76 vs. 308.44 µmol/L pre- and post-ride, respectively), lactate (p = 0.01, median 2.98 vs. 4.8 mmol/L) and C-reactive protein (p = 0.01, 0.0-0.01 mg/L). It is noteworthy that our work supports the studies demonstrating an increased PSA after mechanical manipulation of the prostate. The subjects exhibited either significantly higher post-ride tPSA (p = 0.002, median 0.69 vs. 1.1 ng/mL pre- and post-ride, respectively) and fPSA (p = 0.028, median 0.25 vs. 0.35 ng/mL). Contrary to that, sarcosine levels were not significantly affected by physical exercise (p = 0.20, median 1.64 vs. 1.92 µmol/mL for serum sarcosine, and p = 0.15, median 0.02 µmol/mmol of creatinine vs. 0.01 µmol/mmol of creatinine for urinary sarcosine). Taken together, our pilot study provides the first evidence that the potential biomarker of PCa-sarcosine does not have a drawback by means of a bicycle riding-induced false positivity, as was shown in the case of PSA.

• Authors: Zbynek Heger, Jaromir Gumulec, Ales Ondrak, Jan Skoda, Zdenek Zitka, Natalia Cernei, Michal Masarik, Ondrej Zitka, Vojtech Adam
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 17 Issue 3 Pg. 377 (Mar 17 2016) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 26999116 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Uric Acid
• Lactic Acid
• C-Reactive Protein
• Prostate-Specific Antigen
• Sarcosine

Topics

• Bicycling
• Biomarkers, Tumor (blood, urine)
• C-Reactive Protein (analysis)
• Humans
• Lactic Acid (blood)
• Male
• Middle Aged
• Prostate-Specific Antigen (blood)
• Prostatic Neoplasms (blood, diagnosis)
• Reproducibility of Results
• Sarcosine (blood, urine)
• Uric Acid (blood)